Mark Rouse's artistic journey is a testament to resilience and transformation. In 2015, he was declared legally blind due to diabetic retinopathy, a challenging diagnosis that would alter the course of his creative career. However, after undergoing nine surgeries over a span of three years, his vision was restored, a life-changing experience that profoundly influenced his approach to art and the subjects he chooses to explore.

Rouse's artistic style is a unique blend that he describes as lying at the crossroads of cognitive resonance, emotional investment, and technical skill—elements he refers to as Head, Heart, and Hands. This philosophy underpins his creative process, ensuring that each piece he creates carries a narrative, evokes emotion, and demonstrates a mastery of appropriate technique. His work leans towards objective abstraction, a stylistic choice that reflects the subjects he holds dear.

Throughout his career, Rouse has showcased his works in numerous juried exhibitions across Indiana. His talent has been recognized with several accolades, including the Best of Show and People's Choice awards at the annual Fishers Arts Council/Jiffy Lube Juried Exhibit. He has also secured first and second place in the "Welcome Home" exhibition at the Anderson Museum of Art. His artwork has appealed to collectors worldwide, with prints in possession of enthusiasts across Europe, South America, Australia, and 42 different states in the U.S.

Since regaining his sight, Rouse has been driven by a desire to capture and celebrate cherished elements of his life—memories, travels, people, and his faith. Through his art, he aims to evoke a sense of nostalgia and anticipation, encouraging viewers to reminisce about beloved past experiences or look forward to joyful and unifying moments ahead. Mark Rouse's work is not just about visual expression; it is a heartfelt invitation to connect with one's own emotions and stories.